Microbiota Immune Response Regulation technology

REVEALED: Secret cutting-edge research behind the ‘greatest technological breakthrough in Skin Health for over 100 years’

By Sam Wallen Russell (MPhys), Kit Wallen Russell (MSci) & Dr. Gavin Anwell

New technology using ‘Good’ Skin Bacteria has allowed to become the first to move the science of gut health to the skin.

Unlocking the secret of the hidden, microbial world of the skin surface, Microbiota Immune Response Regulation (MIRR)™ technology is the game changing science behind the World’s First Ever 100% Truly Natural Face Wash with its ability to empower, NOT change, the skin’s natural environment.

Based on State-of-the-art Microbiological & Immunological research, MIRR technology is the secret behind all JooMo® products their ability to protect against the destructive work of harmful synthetic chemicals and opportunistic pathogenic (‘harmful’) microbes.

A natural equilibrium within the skin cell environment, including skin microbiota, is vital in preserving the tissue homeostasis and local immunity. Skin is a dynamic organ and this vast and complex system of cells interacting in synergy with each other, right down to the smallest, quantum level needs to be preserved, enhanced and protected.

Beyond the Gut…

The importance of internal microbiota (in the stomach and gut) has been the subject of much research and publicity in recent years – including many ‘probiotic’ health proposals.

However, despite the shocking rise in allergy related health problems in the developed world, skin condition – and its effect on overall health – has been a much neglected area. [ref: Solving the Global Skin Health Crisis (pdf)…]

The reality is that there has only been a limited amount of research done on skin environment and the body’s immune system responses, and only now are we beginning to understand the fundamentals of the crucial nature that skin has to play in overall health.

Microbes of the Skin…

The skin is the largest organ in the body and is host to probably the most diverse range of microbes in the human body. The bacteria that inhabit the skin are not uniformly distributed across the body, but even the deepest layers of dead tissue and the living tissue below the epidermis harbor a microbial community.

These skin bacteria are key players in host defence. They directly protect humans from pathogenic invaders and help the immune system to maintain and regulate that delicate balance between effective protection and damaging inflammation.

Institute of Process Research and Development (iPRD), University of Leeds


Institute of Process Research and Development (iPRD),
University of Leeds

Recent studies have illustrated how our ‘good’ skin bacteria interact with each other, with other pathogenic microbes, and with human cells. For instance, Staphylococcus epidermidis secretes antimicrobial substances that help fight pathogenic invaders, while Propionibacterium acnes uses the skin’s lipids to generate short-chain fatty acids that can similarly ward off microbial threats.

These and other skin microbes may also be able to alter the behavior of human immune cells, and impact the local molecular environment. Recent trials have been able to show that adding Staphylococcus epidermidis microbes to sterile skin enabled the immune system to control infection by altering the function of T-cells (a key component of the body’s adaptive immune response) to boost host immunity. Researchers have found that different microbes affect distinct parts of the immune system, and how they communicate with the immune system is highly specific to each microbe.

However, while some microbes are able to control aspects of immunity, others are able to promote inflammation and encourage infection. So, while some microbes are secreting protective antimicrobials, others are inducing our skin cells to release disease triggering substances. People with compromised immune systems, therefore, harbor bacterial and fungal species not normally found on healthy adults. Defects in the immune system allows or permits these otherwise uncommon microbes to be present.

Encouraging Biodiversity

To maximise the efficiency of the immune system, ‘natural’ skin uses many complex interlinked techniques to create the most efficient environment. The following is an overview of just a few of the main protective processes involved:

» Skin pH: it has been shown that an acid skin pH (4-4.5) keeps the resident bacterial flora (‘good bacteria’) attached to the skin, whereas an alkaline pH (8-9) promotes their dispersal from the skin.

» Sebaceous glands secrete the oily, waxy substance called sebum, a hydrophobic coating that protects and lubricates the skin and hair and provides an antibacterial shield. Sebum promotes the growth of bacteria such as Propionibacterium acnes, which, by hydrolyzing the fats and oils present in sebum, releases free fatty acids thereby contributing to the maintenance of the acidic skin pH.

» Eccrine sweat glands are the main sweat glands of the human body, found in virtually all skin. They produce a clear, odorless substance, consisting primarily of water, salt (NaCl) and other electrolytes which work to acidify the skin. On the whole, the result of this process is a cool, dry, and slightly acidic envronment that plays a major role in limiting the composition of microbes that can survive and proliferate. Furthermore, eccrine sweat glands express several antimicrobial peptides (AMPs), including cathelicidin and β-defensins, and produces a powerful natural antibiotic called dermcidin. Thus, the density of eccrine sweat glands impacts microbial colonization of the skin.

Use of normal cosmetic products, especially soaps, have profound detrimental influence on skin surface pH, the electrolyte levels, the microbial composition and sebum levels. This leads to pathogenic bacterial, viral and fungal growth with long term immune system malfunction and allergy problems. MIRR technology keeps the skin’s natural defences intact, and restores, rebuilds, repairs and stimulates the skin’s natural immune system by creating the correct environment for synergistic microbial biodiversity to flourish.

JooMo® are pioneering a new generation of research into this complex science to expose the cosmetics industry and change it into a research based, health preserving industry, not a deceitful, multi billion dollar cover up that is detrimental not only to the world’s health but also detrimental to our lives as a whole.

(Article note: Scientific, health and environmental research study references…)


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